Santariškių g. 2, 08661 Vilnius
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Scientific activity


The centre is always engaged in scientific activity. The most important topics include interstital pulmonary diseases (sarcoidosis, idiopathic interstitial pneumonia, eosinophilic pneumonia, etc), pleural diseases (parapneumotic, malign, tuberculous and other types of pleuritis) research, drug allergies, chronic Urticaria, chronic obstructive pulmonary diseases, and the pathogenesis, diagnosis, progression and treatment of pneumonia. The Center of Pulmonology and Allergology also regularly carries out both commercial (pharmaceutical company-funded) and non-commercial clinical trials. The workers at the center have completed 9 scientific doctors' dissertations, 2 habilitated scientific doctors' dissertations, and 1 habilitation process. One medical doctor's scientific dissertation is currently being prepared. Completed medical science doctoral dissertations include - “The pathogenetic and clinical aspects of penicillin allergies in patients suffering from non-specific pulmonary diseases” (Audra Blažienė, 1987), “The role of fungus in patients suffering from respiratory system allergosis” (Marius Zolubas, 1992), “Early diagnosis and correction of bronchial permeability disorders in the relatively healthy and in patients suffering from protracted acute bronchitis” (Remigijus Valdemaras Nargėla, 1993), “the comparison of methods for evaluating endobronchitis in patients suffering from chronic bronchitis” (Edvardas Danila,1999), “Evaluation of the quality of life of patients suffering from bronchial asthma” (Aleksandras Balbieris, 2001), “The diagnostic value of pleural fluid test methods” (Rolandas Zablockis, 2003), “Basophil CD63 marker test significance in drug allergy diagnosis” (Violeta Kvedarienė, 2008), “Diagnostic significance of autoreactive indicators for patients suffering from chronic urticaria” (Anželika Chomičienė, 2009), and “The effects of bronchial inflammation on pulmonary function in patients suffering from chronic obstructive pulmonary diseases” (Virginija Šileikienė, 2013).

Completed habilitated medical science doctoral dissertations include - “Complex pathogenetic testing of various bronchial asthma tests” (Bronislovas Šatkauskas, 1991), (The evaluation of the functional condition of the respiratory system in individuals with heightened levels of motor activity” (Artūras Andžiulis, 2001). In 2009, Edvardas Danila completed the habilitation procedure with a thesis on “Evaluation of interstitial pulmonary disease diagnostic methods.”

The Center for Pulmonology and Allergology's workers prepare scientific conferences every year, at least two of which are national. The center's physicians have read more than several hundred announcements at national and international conferences and congresses, published several hundred scientific articles, and have published dozens of textbooks, educational books and methodical recommendations. You will find the past year's most important publications below:

Articles Published in the ISI Web of Science Journals in 2001-2013


1. Lebel B, Messaad D, Kvedarienė V, Rongier M, Bousquet J, Demoly P. Cysteinyl-leukotriene release test (CAST) in the diagnosis of immediate drug reactions. Allergy 2001; 56(7): 688–692.
2. Blažienė A, Nolte H., DuBuske LM et. al. Prevalence of skin test reactions to natural rubber latex in hospital personnel in Russia and eastern Europe. Annals of Allergy, Asthma & Immunology 2002; 89: 452–456.
3. Kvedarienė V, Bencherioua AM, Messaad D, Godard P, Bousquet J, Demoly P. The accuracy of the diagnosis of suspected paracetamol (acetaminophen) hypersensitivity: results of a single-blinded trial. Clin Exp Allergy 2002; 32(9):1366–1369.
4. Piette V, Bousquet C, Kvedarienė V, Dhivert-Donnadieu H, Crampette L, Senac JP et al. Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens. Allergy 2004; 59(8): 863–868.
5. Kvedarienė V, Kamey S, Ryckwaert Y, Rongier M, Bousquet J, Demoly P, Arnoux B. Diagnosis of neuromuscular blocking agent hypersensitivity reactions using cytofluorimetric analysis of basophils. Allergy 2006; 61(3): 311–315.
6. Co Minh HB, Bousquet PJ, Fontaine C, Kvedarienė V, Demoly P. Systemic reactions during skin tests with beta-lactams: a risk factor analysis. J Allergy Clin Immunol 2006; 117(2): 466–468.
7. Kvedarienė V, Martins P, Rouanet L, Demoly P. Diagnosis of iodinated contrast media hypersensitivity: results of a 6-year period. Clin Exp Allergy 2006; 36(8): 1072–1077.
8. Bousquet J, van Cauwenberge P, Aït Khaled N, Bachert C, Baena-Cagnani CE, Bouchard J, Dubakiene R, Kvedarienė V et al. Pharmacologic and anti-IgE treatment of allergic rhinitis ARIA update (in collaboration with GA2LEN). Allergy 2006; 61(9): 1086–1096.
9. Grigaitienė J., Marčiukaitienė I., Blažienė A., Chomičienė A. Apoptozės tyrimas normalios odos audiniuose. Medicina 2007; 43(4): 301–304.
10. Bousquet PJ, Kvedarienė V, Co-Minh HB, Martins P, Rongier M, Arnoux B, Demoly P. Clinical presentation and time course in hypersensitivity reactions to beta-lactams. Allergy 2007; 62(8): 872–876.
11. Danila E, Žurauskas E, Loskutovienė G, Zablockis R, Nargėla R, Biržietytė V, Valentinavičienė G. Significance of bronchoscopic lung biopsy in clinical practice. Adv Med Sci 2008; 53: 11–16.
12. Danila E, Jurgauskienė L, Malickaitė R. BAL fluid cells and pulmonary function in different radiographic stages of newly diagnosed sarcoidosis. Adv Med Sci 2008; 53: 228–233.
13. Danila E, Žurauskas E. Diagnostic value of epithelioid cell granulomas in bronchoscopic biopsies. Inter Med 2008; 47: 2121–2126.
14. Kvedarienė V, Demoly P. The need for a biological diagnosis of penicillin allergy. Clin Exp Allergy 2008; 38(6): 869–871.
15. Danila E, Jurgauskienė L, Norkūnienė J, Malickaitė R. BAL fluid cells in newly diagnosed pulmonary sarcoidosis with different clinical activity. Ups J Med Sci 2009; 114: 26–31.
16. Danila E, Norkūnienė J, Jurgauskienė L, Malickaitė R. Diagnostic role of BAL fluid CD4/CD8 ratio in different radiographic and clinical forms of pulmonary sarcoidosis. Clin Respir J 2009; 3: 214–221.
17. Danila E, Šileikienė V, Nargėla R, Žurauskas E, Loskutovienė G. Different courses of silicosis in four brothers of one family. Int J Occup Med Environ Health 2009; 22: 51–57.
18. Bousquet PJ, Demoly P, Romano A, Aberer W, Bircher A, Blanca M, Kvedarienė V et al. Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project. Allergy 2009; 64(2): 194–203.
19. Danila E, Norkūnienė J, Nargėla R, Žurauskas E, Šatkauskas B, Aleksonienė R. Manifestation peculiarities of idiopathic chronic eosinophilic pneumonia. Cent Eur J Med 2010; 5: 75–82.
20. Zablockis R, Petruškevičienė R, Nargėla RV. Pleuros empiemos ir komplikuoto parapneumoninio pleurito priežastys ir rizikos veiksniai. Medicina 2010; 46(2): 113–119.
21. Grigienė G, Norkūnienė J, Kvedarienė V. The time delay between drug intake and bronchospasm for nonsteroidal antiinflammatory drugs sensitive patients. WAO Journal 2010; 3(12): 266–270.
22. Gomes ER, Kvedarienė V, Demoly P, Bousquet PJ. Patients' satisfaction with diagnostic drug provocation tests and perception of its usefulness. Int Arch Allergy Immunol 2011; 156(3): 333–338.
23. Zinkevičienė A, Vaičiulionienė N, Baranauskienė I, Kvedarienė V, Emuzytė R, Citavičius D. Cutaneous yeast microflora in patients with atopic dermatitis. Cent Eur J Med 2011; 6: 713719.
24. Malakauskas K, Zablockis R, Venalis A, Butrimienė I, Baranauskaitė A, Nargėla RV, Sakalauskas R. Tuberkuliozės prevencijos ir gydymo rekomendacijos skiriant naviko nekrozės faktoriaus alfa blokatorius (Lietuvos pulmonologų ir reumatologų sutarimas). Medicina 2011; 47(3): 187189.
25. Danila E, Zablockis R, Norkūnienė J, Žurauskas E. Organizing pneumonia: manifestation peculiarities, causes and outcome. Cent Eur J Med 2011; 6: 356–362
26. Mertes PM, Malinovsky JM, Jouffroy L, Aberer W, Terreehorst I, Brockow K, Demoly P, Kvedarienė V. Reducing the risk of anaphylaxis during anesthesia: 2011 updated guidelines for clinical practice. J Investig Allergol Clin Immunol 2011; 21 (6): 442–453.
27. Gomes ER, Kvedarienė V, Demoly P, Bousquet PJ. Patients' satisfaction with diagnostic drug provocation tests and perception of its usefulness. Int Arch Allergy Immunol 2011; 156: 333–338.
Mertes PM, Malinovsky JM, Jouffroy L, Aberer W, Terreehorst I, Brockow K, Demoly P, Kvedarienė V. Reducing the risk of anaphylaxis during anesthesia: 2011 updated guidelines for clinical practice. J Investig Allergol Clin Immunol 2011; 21: 442–453.
Malinauskienė L, Zimerson E, Bruze M, Ryberg K, Isaksson M. The commercial textile dyes disperse orange 1 and disperse yellow 3 contain more than one allergen as shown by patch testing with thin layer chromatograms. Dermatitis: 2011; 22: 335–343.
Bousquet J, Schünemann HJ, Samolinski B, Dubakienė R, Ėmužytė R, Kvedarienė V, Valiulis A. Allergic rhinitis and its impact on asthma (ARIA): Achievements in 10 years and future needs. J Allergy Clin Immunol 2012; 130: 1049–1062.
Malinauskienė L, Zimerson E, Bruze M, Ryberg K, Isaksson M. Patch testing with the textile dyes disperse orange 1 and disperse yellow 3 and some of their potential metabolites, and simultaneous reactions to para-amino compounds. Contact Dermatitis. 2012; 67: 130–140.
Malinauskienė L, Zimerson E, Bruze M, Ryberg K, Isaksson M. Are allergenic disperse dyes used for dyeing textiles? Contact Dermatitis. 2012; 67: 141–48.
Malinauskienė L, Isaksson M, Bruze M. Systemic contact dermatitis in a gold-allergic patient after treatment with an oral homeopathic drug. J Am Acad Dermatol. 2013; 68: e58.
Malinauskienė L, Bruze M, Ryberg K, Zimerson E, Isaksson M. Contact allergy from disperse dyes in textiles – a review. Contact Dermatitis. 2013; 68: 65–75.
Malinauskienė L, Isaksson M. Protein contact dermatitis caused by allergy to Chapatti flour. Acta Derm Venereol. 2013; 93: 91–93.
Malinauskienė L, Zimerson E, Bruze M, Ryberg K, Isaksson M. Sensitizing capacity of disperse orange 1 and its potential metabolites from azo reduction and their cross-reactivity pattern. Contact Dermatitis 2013; 69: 4048.
Atnaujinta 2014-06-04
Straipsnis parodytas: 12940 kartų(kartus)
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